反应详情

温度

0 °C

To a solution of 3H-isobenzofuran-1-one (18 g, 134 mmol) in dry N,N-dimethylformamide (110 mL) was added potassium phthalimide (27 g, 145 mmol). The mixture was stirred at reflux for 6 hours then cooled to 0° C. and treated with 1N hydrochloric acid (180 mL). The yellow solid thus formed was filtered, washed with water, with ethanol and dried in oven. Crystallization with ethanol afforded the title compound as white solid (27 g).

1. temperatureat reflux for 6 hours
2. customThe yellow solid thus formed
3. filtrationwas filtered
4. washwashed with water, with ethanol
5. customdried in oven
6. customCrystallization with ethanol