Methanol → Tert-butyl 6-(4-carboxyphenyl)-spiro[2.5]octane-1-carboxylate

HRID 125686Notes

Reaction equation

HRID 125686 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([CH:12]2[CH2:13][CH2:14][C:15]3([CH2:16][CH:17]3[C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:25][CH2:26]2)[cH:10][cH:11]1.[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:32][OH:33].[Li+:36].[OH-:35].[OH2:34].[OH2:37]>>[O:3]=[C:4]([OH:5])[c:6]1[cH:7][cH:8][c:9]([CH:12]2[CH2:13][CH2:14][C:15]3([CH2:16][CH:17]3[C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:25][CH2:26]2)[cH:10][cH:11]1

Participants

7

Reactant 6

HCID 887MethanolHCID 961HydroxideHCID 962Water2×HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 66740128HCID 66740128, compound

Product 1

HCID 66739947Tert-butyl 6-(4-carboxyphenyl)-spiro[2.5]octane-1-carboxylate

Sources & evidence

ORD record
ord-846da172d28740db984bf8028803ad09
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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