Diethyl Malonate → HCID 11460315, compound

HRID 1256879Notes

Reaction equation

HRID 1256879 reaction equation
[C:1]([O:9][CH2:10][CH3:11])(=[O:8])[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[Cl:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Br)=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:1]([O:9][CH2:10][CH3:11])=[O:8])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 7761Diethyl MalonateHCID 693291-(Bromomethyl)-4-chlorobenzene

Product 1

HCID 11460315HCID 11460315, compoundYield 41.8%

Procedure

In the same manner as in Example 6 (1), a crude product was obtained using diethyl malonate (13.6 g) and 4-chlorobenzyl bromide (17.5 g). This was purified by silica gel column chromatography to give the title compound (10.1 g) as an oil.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-cdcd98bac78c4c87b4d1c52e95658a85
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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