反应详情

To a mixed solvent of toluene (100 mL)/ethanol (100 mL)/water (50 mL) were added benzyl bromide (10.7 g) and sodium azide (10.1 g), and the mixture was heated under reflux for 5 hr. A solution of ethyl acrylate (38.8 mL) in ethanol (200 mL) was added dropwise to the reaction mixture, and the mixture was heated under reflux for 12 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give the title compound (5.66 g) as an oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 5 hr
3. temperaturethe mixture was heated
4. temperatureunder reflux for 12 hr
5. concentrationThe reaction mixture was concentrated under reduced pressure
6. customthe residue was purified by silica gel column chromatography