反应详情

To a solution (4 mL) of the crude compound (310 mg, 0.88 mmol) obtained in Example 26a in tetrahydrofuran were added triethylamine (0.16 mL, 1.1 mmol) and acetoxyacetylchloride (145 mg, 1.1 mmol), and the mixture was stirred at room temperature overnight. After confirmation of the termination of the reaction by TLC, the resulting salt was removed. The solvent was evaporated under reduced pressure. The resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=7/3) to give the title compound (270 mg, 72% in 2 steps) as a colorless oil.

1. customAfter confirmation of the termination of the reaction by TLC
2. customthe resulting salt was removed
3. customThe solvent was evaporated under reduced pressure
4. customThe resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=7/3)