Acetyl chloride → HCID 66939415, compound

HRID 1257372Notes

Reaction equation

HRID 1257372 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=2)[CH:6]=[CH:7][CH:8]=1.[C:18](Cl)(=[O:20])[CH3:19].C(N(CC)CC)C>O1CCCC1>[C:18]([O:15][CH2:14][C:12]1[N:13]=[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:16])[F:17])[CH:4]=2)[S:10][CH:11]=1)(=[O:20])[CH3:19]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 56706473HCID 56706473, compound

Product 1

HCID 66939415HCID 66939415, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Under a nitrogen atmosphere at 0° C., to a solution (21 mL) of the compound (5.4 g, 21 mmol) obtained in Example 64b in tetrahydrofuran were added acetyl chloride (2.0 g, 25 mmol) and triethylamine (3.8 mL, 27 mmol), and the mixture was stirred at room temperature for 30 min. The resulting salt was removed and the solvent was evaporated under reduced pressure to give a crude title compound as a colorless solid.

Workup

  1. customThe resulting salt was removed
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f80136fb666f4f5da8af342d3cc39c96
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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