Hydrochloric Acid → HCID 66939369, compound

HRID 1257413Notes

Reaction equation

HRID 1257413 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[O:13][CH:14]=[C:15]([CH2:17][N:18]2[CH:22]=[C:21]([C:23]([O:25]CC)=[O:24])[CH:20]=[N:19]2)[N:16]=1.[OH-].[Na+].C(O)C.Cl>O1CCCC1>[F:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[O:13][CH:14]=[C:15]([CH2:17][N:18]2[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[CH:20]=[N:19]2)[N:16]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 66939284HCID 66939284, compound

Product 1

HCID 66939369HCID 66939369, compoundYield 78.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of the compound (0.44 g) obtained in Example 105b, 4N sodium hydroxide (3 mL), ethanol (8 mL) and tetrahydrofuran (2 mL) was stirred at room temperature for 16 hr. The reaction mixture was adjusted to pH 5 with 1N hydrochloric acid, and the precipitate was collected by filtration, dried under reduced pressure and recrystallized from ethanol-hexane to give the title compound (0.32 g) as colorless crystals.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customdried under reduced pressure
  3. customrecrystallized from ethanol-hexane

Sources & evidence

ORD record
ord-9fd40d7fff4648aa8b54e4489c064a35
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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