HCID 58127681, compound → HCID 58127974, compound

HRID 1257424Notes

Reaction equation

HRID 1257424 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12]([CH2:14][N:15]3[CH:19]=[C:18]([C:20]([O:22]CC4C=CC=CC=4)=[O:21])[CH:17]=[N:16]3)=[N:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1>C(OCC)(=O)C.[C].[Pd]>[F:31][C:2]([F:1])([F:30])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12]([CH2:14][N:15]3[CH:19]=[C:18]([C:20]([OH:22])=[O:21])[CH:17]=[N:16]3)=[N:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 58127681HCID 58127681, compound

Product 1

HCID 58127974HCID 58127974, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The compound (0.08 g) obtained in Example 122b was dissolved in ethyl acetate (2 ml), palladium carbon (5 mg) was added, and the mixture was stirred under a hydrogen atmosphere at room temperature overnight. Palladium carbon was removed by filtration, and the solvent was evaporated from the filtrate under reduced pressure to give the title compound (0.06 g) as a colorless solid.

Workup

  1. customPalladium carbon was removed by filtration
  2. customthe solvent was evaporated from the filtrate under reduced pressure

Sources & evidence

ORD record
ord-ee1661a1b76c4c85b97698170ced9361
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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