Hydroxyamine hydrochloride → HCID 85344664, compound

HRID 1257471Notes

Reaction equation

HRID 1257471 reaction equation
[C:1]([CH2:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)#[N:2].C(=O)([O-])O.[Na+].Cl.[NH2:20][OH:21]>CO>[NH2:2][C:1](=[N:20][OH:21])[CH2:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 848548Methyl 4-(cyanomethyl)benzoate

Product 1

HCID 85344664HCID 85344664, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-(cyanomethyl)benzoate (2.0 g) was suspended in methanol (30 mL), and sodium hydrogen carbonate (0.96 g) and hydroxylamine hydrochloride (0.80 g) were added. The reaction mixture was heated under reflux for 12 hr, and the insoluble material was removed by filtration. The solvent was evaporated under reduced pressure from the obtained filtrate to give the title compound as a bister solid.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 12 hr
  3. customthe insoluble material was removed by filtration
  4. customThe solvent was evaporated under reduced pressure from the obtained filtrate

Sources & evidence

ORD record
ord-849b6d0fb0db4bb5a896cfe623d3efd9
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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