Trifluoroacetic acid → HCID 67224038, compound

HRID 1257895Notes

Reaction equation

HRID 1257895 reaction equation
FC(F)(F)C(O)=O.[N:8]1[C:17]2[C:12](=[CH:13][C:14]([CH2:18][C:19]3[N:23]4[N:24]=[C:25]([C:28]5[CH:29]=[N:30][N:31]([CH:33]6[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]6)[CH:32]=5)[CH:26]=[N:27][C:22]4=[N:21][CH:20]=3)=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1>C(Cl)Cl>[NH:36]1[CH2:37][CH2:38][CH:33]([N:31]2[CH:32]=[C:28]([C:25]3[CH:26]=[N:27][C:22]4[N:23]([C:19]([CH2:18][C:14]5[CH:13]=[C:12]6[C:17](=[CH:16][CH:15]=5)[N:8]=[CH:9][CH:10]=[CH:11]6)=[CH:20][N:21]=4)[N:24]=3)[CH:29]=[N:30]2)[CH2:34][CH2:35]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67224311HCID 67224311, compound

Product 1

HCID 67224038HCID 67224038, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic Acid (0.5 mL) was added to a solution of tert-butyl 4-{4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-1H-pyrazol-1-yl}piperidine-1-carboxylate (0.014 g, 0.027 mmol) in methylene chloride (0.5 mL) and stirred at RT for 1 h. The volatiles were removed under reduced pressure and the residue was purified by RP-HPLC (pH 10) to give the desired product. LCMS: (M+H)=411.1.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customthe residue was purified by RP-HPLC (pH 10)

Sources & evidence

ORD record
ord-f33998f4582d41b797811cf54c0aa848
Source dataset
uspto-grants-2013_06
Patent number
US08461330B2

Reaction notes

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