反应详情

To a solution of Z-(L)Glu(OtBu)-OH (25.2 g) in DCM/THF (240 mL/60 mL) were added EDCI hydrochloride (17.2 g), HOBT hydrate (13.7 g) and DIPEA (28.2 mL). After stirring at RT for 5 min, intermediate 1.2 (20 g) was added. The mixture was stirred at RT overnight. DCM and water were added and the phases were separated. The org. phase was washed with 2M Na2CO3, with 1M NaHSO4 and with brine, was dried (Na2SO4) and evaporated off. Drying under HV gave the desired compound as an orange oil (40 g).

1. stirringThe mixture was stirred at RT overnight
2. customthe phases were separated
3. washphase was washed with 2M Na2CO3, with 1M NaHSO4 and with brine
4. dry with materialwas dried (Na2SO4)
5. customevaporated off
6. customDrying under HV