反应详情

To a solution of 2,6-bis(chloromethyl)pyridine (20 g, 113.6 mmol, 1 eq.) in 250 ml of DMF was added potassium phthalimide (21.04 g, 113.6 mmol, 1 eq.). The reaction was stirred at r.t. overnight then the solvent was evaporated and the residue taken in EtOAc. The insolubles were removed by filtration and the filtrate washed with H2O. The organic layer was separated, dried over MgSO4 and concentrated. The resulting white solid was recrystallised from IPE/EtOAc (1/1) to give 2-{[6-(chloromethyl)pyridin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione (22.34 g, 68% yield) as a white solid.

1. customthe solvent was evaporated
2. customThe insolubles were removed by filtration
3. washthe filtrate washed with H2O
4. customThe organic layer was separated
5. dry with materialdried over MgSO4
6. concentrationconcentrated
7. customThe resulting white solid was recrystallised from IPE/EtOAc (1/1)