Hydrochloric Acid → HCID 178509819, compound

HRID 1258644Notes

Reaction equation

HRID 1258644 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([NH:16][C:17]2[NH:21][C:20]3[CH:22]=[C:23]([N:27]4[CH2:33][CH2:32][C:29]5([CH2:31][CH2:30]5)[CH2:28]4)[C:24]([Cl:26])=[CH:25][C:19]=3[N:18]=2)[CH:10]=1)(C)(C)C.Cl>C1COCC1>[CH2:30]1[C:29]2([CH2:32][CH2:33][N:27]([C:23]3[C:24]([Cl:26])=[CH:25][C:19]4[N:18]=[C:17]([NH:16][C:11]5[CH:10]=[C:9]([CH:14]=[CH:13][C:12]=5[Cl:15])[CH2:8][NH2:7])[NH:21][C:20]=4[CH:22]=3)[CH2:28]2)[CH2:31]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453056HCID 178453056, compound

Product 1

HCID 178509819HCID 178509819, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The sub-title compound was prepared in analogy to example 3, step (d) from {3-[6-(5-aza-spiro[2.4]hept-5-yl)-5-chloro-1H-benzimidazol-2-ylamino]-4-chloro-benzyl}-carbamic acid tert-butyl ester (50 mg, 0.1 mmol) and 6 M aq. HCl (0.40 mL) in THF (2 mL).

Sources & evidence

ORD record
ord-80290da4fa3b4e369fa36713ebe1398d
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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