Pivaloyl chloride → HCID 178447318, compound

HRID 1258645Notes

Reaction equation

HRID 1258645 reaction equation
[CH2:1]1[C:3]2([CH2:7][CH2:6][N:5]([C:8]3[C:9]([Cl:27])=[CH:10][C:11]4[N:15]=[C:14]([NH:16][C:17]5[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=5[Cl:25])[CH2:20][NH2:21])[NH:13][C:12]=4[CH:26]=3)[CH2:4]2)[CH2:2]1.[C:28](Cl)(=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30]>C1COCC1>[CH2:2]1[C:3]2([CH2:7][CH2:6][N:5]([C:8]3[C:9]([Cl:27])=[CH:10][C:11]4[N:15]=[C:14]([NH:16][C:17]5[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=5[Cl:25])[CH2:20][NH:21][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])[NH:13][C:12]=4[CH:26]=3)[CH2:4]2)[CH2:1]1

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 178509819HCID 178509819, compound

Product 1

HCID 178447318HCID 178447318, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The sub-title compound was prepared from 3-[6-(5-aza-spiro[2.4]hept-5-yl)-5-chloro-1H-benzimidazol-2-ylamino]-4-chloro-benzylamine (60 mg, 0.1), pivaloyl chloride (20 μL, 0.1 mmol) and TEA (160 μL, 1.1 mmol) in THF (5 mL) in analogy to example 3, step (e).

Sources & evidence

ORD record
ord-bc4a7eb800ef4e18be7c619db5aff167
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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