Hydrochloric Acid → HCID 178483240, compound

HRID 1258659Notes

Reaction equation

HRID 1258659 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([NH:16][C:17]2[NH:21][C:20]3[CH:22]=[C:23]([N:27]4[CH2:31][CH2:30][CH2:29][CH:28]4[CH2:32][N:33]([CH3:35])[CH3:34])[C:24]([Cl:26])=[CH:25][C:19]=3[N:18]=2)[CH:10]=1)(C)(C)C.Cl>C1COCC1>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][NH2:7])=[CH:10][C:11]=1[NH:16][C:17]1[NH:21][C:20]2[CH:22]=[C:23]([N:27]3[CH2:31][CH2:30][CH2:29][CH:28]3[CH2:32][N:33]([CH3:35])[CH3:34])[C:24]([Cl:26])=[CH:25][C:19]=2[N:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178483242HCID 178483242, compound

Product 1

HCID 178483240HCID 178483240, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The sub-title compound was prepared from {4-chloro-3-[5-chloro-6-(2-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-carbamic acid tert-butyl ester (20 mg, 0.04 mmol) and 6 M aq. HCl-solution (1.0 ml) in THF (2 mL) in analogy to example 3 step (d).

Sources & evidence

ORD record
ord-9ecc3713255f404495e1bce9e05c3791
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

Loading…