Pivaloyl chloride → HCID 178483241, compound

HRID 1258660Notes

Reaction equation

HRID 1258660 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][C:3]=1[NH:10][C:11]1[NH:15][C:14]2[CH:16]=[C:17]([N:21]3[CH2:25][CH2:24][CH2:23][CH:22]3[CH2:26][N:27]([CH3:29])[CH3:28])[C:18]([Cl:20])=[CH:19][C:13]=2[N:12]=1.[C:30](Cl)(=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32]>C1COCC1>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH:7][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:4][C:3]=1[NH:10][C:11]1[NH:15][C:14]2[CH:16]=[C:17]([N:21]3[CH2:25][CH2:24][CH2:23][CH:22]3[CH2:26][N:27]([CH3:29])[CH3:28])[C:18]([Cl:20])=[CH:19][C:13]=2[N:12]=1

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 178483240HCID 178483240, compound

Product 1

HCID 178483241HCID 178483241, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared analogously to example 3 step (e) from 4-chloro-3-[5-chloro-6-(2-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzylamine (30 mg), pivaloyl chloride (10 μL, 0.06 mmol) and TEA (70 μL, 0.54 mmol) in THF (2 mL).

Sources & evidence

ORD record
ord-8a82ba121c964ca5a4d1301c7326a996
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

Loading…