反应详情

Tin dichloride dihydrate (410 mg, 1.8 mmol) was added to 1-(5-amino-2-chloro-4-nitro-phenyl)-pyrrolidine-3-carbonitrile (100 mg, 0.4 mmol) in EtOAc (5 mL). The reaction mixture was stirred at reflux for 1.5 h, cooled, diluted with EtOAc and water and basified with conc. ammonia. The mixture was filtered through a pad of celite. The organic layer was dried over Na2SO4 and concentrated to give the sub-title compound.

1. temperatureat reflux for 1.5 h
2. temperaturecooled
3. filtrationThe mixture was filtered through a pad of celite
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated