Tetrahydrofuran → HCID 67957699, compound

HRID 1258691Notes

Reaction equation

HRID 1258691 reaction equation
[Cl:1][C:2]1[C:8]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[CH:7][C:5]([NH2:6])=[C:4]([N+:19]([O-])=O)[CH:3]=1.C1COCC1>CO>[Cl:1][C:2]1[C:8]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([F:16])([F:17])[F:18])[CH2:11][CH2:10]2)=[CH:7][C:5]([NH2:6])=[C:4]([NH2:19])[CH:3]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 44120656HCID 44120656, compound

Product 1

HCID 67957699HCID 67957699, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-chloro-2-nitro-5-(4-trifluoromethyl-piperidin-1-yl)aniline (0.63 g, 1.9 mmol), THF (10 mL), MeOH (20 mL) and 50%-Pt-on-carbon (60 mg) was stirred for 22 h at rt under a hydrogen atmosphere (3 bar). The catalyst was removed by filtration and the mixture was concentrated to give the sub-title compound.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-b93fd3d83af74caba6a6b39b17106b45
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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