反应详情

A mixture of N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide (200 mg; 0.60 mmol) and 5-chloro-2-methylamino-4-(4-phenyl-piperidin-1-yl)aniline (190 mg; 0.60 mmol) in DMF (4 mL) was stirred overnight at rt. DIC (76 mg; 0.60 mmol) was added and the mixture was heated at 90° C. for 1.5 h. The mixture was poured in water, extracted with EtOAc and the combined organic layer was dried over Na2SO4, filtered and concentrated and the residue was purified by column chromatography.

1. temperaturethe mixture was heated at 90° C. for 1.5 h
2. extractionextracted with EtOAc
3. dry with materialthe combined organic layer was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customthe residue was purified by column chromatography