Diisopropylcarbodiimide → HCID 60162015, compound

HRID 1258713Notes

Reaction equation

HRID 1258713 reaction equation
[F:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][CH:14]([C:17]([F:20])([F:19])[F:18])[CH2:13][CH2:12]2)=[CH:4][C:5]([NH:9][CH3:10])=[C:6]([CH:8]=1)[NH2:7].[Cl:21][C:22]1[CH:38]=[CH:37][C:25]([CH2:26][NH:27][C:28]([C:30]2([C:33]([F:36])([F:35])[F:34])[CH2:32][CH2:31]2)=[O:29])=[CH:24][C:23]=1[N:39]=[C:40]=S.CC(C)N=C=NC(C)C>CN(C=O)C>[Cl:21][C:22]1[CH:38]=[CH:37][C:25]([CH2:26][NH:27][C:28]([C:30]2([C:33]([F:36])([F:35])[F:34])[CH2:32][CH2:31]2)=[O:29])=[CH:24][C:23]=1[NH:39][C:40]1[N:9]([CH3:10])[C:5]2[CH:4]=[C:3]([N:11]3[CH2:16][CH2:15][CH:14]([C:17]([F:19])([F:20])[F:18])[CH2:13][CH2:12]3)[C:2]([F:1])=[CH:8][C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 67957634HCID 67957634, compoundHCID 86646336N-(4-Chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide

Product 1

HCID 60162015HCID 60162015, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared in analogy to Example 76 using 5-fluoro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline (175 mg, 0.60 mmol), N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide (200 mg; 0.60 mmol), DIC (76 mg, 0.60 mmol) and DMF (3 mL).

Sources & evidence

ORD record
ord-69ca527a2fdf42cf8099bb7165386af3
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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