Octane → Sunitinib

HRID 1258773Notes

Reaction equation

HRID 1258773 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][NH:6][C:7]([C:9]1[C:13]([CH3:14])=[C:12]([CH:15]=O)[NH:11][C:10]=1[CH3:17])=[O:8])[CH3:2].[F:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][C:25](=[O:30])[CH2:24]2.CCCCCCCC.CCCCCCCCC.CCCCCCCCCC.N1CCCC1>CCCCCCC.CCCCCC>[CH3:2][CH2:1][N:3]([CH2:4][CH2:5][NH:6][C:7]([C:9]1[C:13]([CH3:14])=[C:12](/[CH:15]=[C:24]2/[C:23]3[CH:22]=[C:21]([F:20])[CH:29]=[CH:28][C:27]=3[NH:26][C:25]/2=[O:30])[NH:11][C:10]=1[CH3:17])=[O:8])[CH2:18][CH3:19]

Participants

9

Reactant 6

HCID 356OctaneHCID 8141NonaneHCID 15600DecaneHCID 31268PyrrolidineHCID 37310125-fluoro-1,3-dihydro-2H-indol-2-oneHCID 20761785N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Product 1

HCID 5329102Sunitinib

Reagents, catalysts & solvents 2

HCID 8058HexaneSolventHCID 8900HeptaneSolvent

Procedure

According to the process of the present invention, 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amide (IX) and 5-Fluoro-1,3-dihydro-indol-2-one (X) in non-polar aliphatic hydrocarbons solvents like n-hexane, n-heptane, n-octane, n-nonane or n-decane are reacted in presence of catalytic amount of pyrrolidine as base at reflux temperature for 6-12 hours. The resultant Sunitinib base is again triturated with the same solvent at reflux temperature for 1-2 hours and isolated at a temperature ranging from 20-45° C., preferably at 25-35° and most preferably at 25-30° C. and dried at 60° C. for 5-20 hours to get Sunitinib base (I) as orange crystalline solid.

Workup

  1. temperatureat reflux temperature for 6-12 hours
  2. customThe resultant Sunitinib base is again triturated with the same solvent
  3. temperatureat reflux temperature for 1-2 hours
  4. customisolated at a temperature
  5. customranging from 20-45° C., preferably at 25-35° and most preferably at 25-30° C.
  6. customdried at 60° C. for 5-20 hours

Sources & evidence

ORD record
ord-4981ea860971461fa66600c48323fc92
Source dataset
uspto-grants-2013_06
Patent number
US08466190B2

Reaction notes

Loading…