3-Amino-3-methyloxetane → HCID 57378671, compound

HRID 1258883Notes

Reaction equation

HRID 1258883 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[N:11][N:10]([CH3:13])[C:9]=2[C:14]2[N:15]=[CH:16][N:17]([C:19]3[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=3)[CH:18]=2)=[CH:4][CH:3]=1.[CH3:28][C:29]1([NH2:33])[CH2:32][O:31][CH2:30]1>C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[N:11][N:10]([CH3:13])[C:9]=2[C:14]2[N:15]=[CH:16][N:17]([C:19]3[CH:27]=[CH:26][C:22]([C:23]([NH:33][C:29]4([CH3:28])[CH2:32][O:31][CH2:30]4)=[O:24])=[CH:21][CH:20]=3)[CH:18]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 67954954HCID 67954954, compound

Product 1

HCID 57378671HCID 57378671, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

As described for example 3b, 4-{4-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-imidazol-1-yl}-benzoic acid (75 mg, 0.21 mmol) was converted, using 3-methyl-3-oxetanamine instead of isopropylamine, to the title compound (57 mg, 64%) which was obtained as a white solid after trituration from ethyl acetate. MS: m/e=433.4 [M+H]+.

Sources & evidence

ORD record
ord-59105d9f4a4d43fd93f87774f6d78a8a
Source dataset
uspto-grants-2013_06
Patent number
US08466181B2

Reaction notes

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