2-Amino-2-methyl-1-propanol → HCID 57377582, compound

HRID 1258922Notes

Reaction equation

HRID 1258922 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:18]4[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][N:19]=4)[CH:17]=3)=[C:11]([CH3:27])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:28][C:29]([CH3:33])([CH3:32])[CH2:30][OH:31]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:18]4[CH:26]=[CH:25][C:21]([C:22]([NH:28][C:29]([CH3:33])([CH3:32])[CH2:30][OH:31])=[O:23])=[CH:20][N:19]=4)[CH:17]=3)=[C:11]([CH3:27])[N:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 67956048HCID 67956048, compound

Product 1

HCID 57377582HCID 57377582, compoundYield 79%

Procedure

As described for example 36b, 6-(4-(1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (65 mg, 0.178 mmol) was converted, using 2-amino-2-methyl-1-propanol instead of isopropylamine, to the title compound (61 mg, 79%) which was obtained as a white solid. MS: m/e=436.2 [M+H]+.

Sources & evidence

ORD record
ord-4ec887212b6b4cb79a171a8a628df985
Source dataset
uspto-grants-2013_06
Patent number
US08466181B2

Reaction notes

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