反应详情

A solution of lithium hydroxide monohydrate (29 mg, 0.671 mmol) in water (1.3 mL) was added dropwise to a suspension of methyl 6-(4-(1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinate (127 mg, 0.336 mmol) in THF (5 mL) and methanol (1 mL). The reaction mixture was then stirred at room temperature for 1 h and was then evaporated and the residue dissolved in water, acidified with HCl (1 N), and the resulting precipitate filtered off to afford the title product (108 mg, 88%) as a white solid. MS: m/e=363.3 [M−H]−.

1. customwas then evaporated
2. dissolutionthe residue dissolved in water
3. filtrationthe resulting precipitate filtered off