反应详情

A mixture of 2.5 g (13.3 mmol) of 2-adamantylamine hydrochloride, 1.84 ml (13.3 mmol) of triethylamine in 50 ml of ethanol was heated under reflux. Then 1.94 ml (13.3 mmol) of 4-methoxy-2-methylphenylisocyanate was added and the mixture was stirred under reflux for 2 h. After cooling at room temperature the precipitate was filtered, washed with ethanol and dried under vacuum to give 4.2 g (61%) a white solid.

1. temperaturewas heated
2. temperatureunder reflux
3. temperatureunder reflux for 2 h
4. filtrationwas filtered
5. washwashed with ethanol
6. customdried under vacuum