反应详情

HBr in acetic acid (20 mL) was added to 1-benzyl-7-(4-bromo-2-fluoro-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (I-1f: 1.4 g) and the resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% ethylacetate). The reaction mixture was partitioned between ice water and ethyl acetate. The organic layer was concentrated to afford the crude product. Purification by column chromatography on silica gel (65% ethylacetate in hexane) afforded 600 mg of the product (54.5% yield).

1. customThe reaction mixture was partitioned between ice water and ethyl acetate
2. concentrationThe organic layer was concentrated
3. customto afford the crude product
4. customPurification by column chromatography on silica gel (65% ethylacetate in hexane)