反应详情

Zinc (284 mg, 0.004 mol) was added to a stirred solution of 7-(4-bromo-2-fluoro-phenylamino)-6-methyl-8-nitro-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-carboxylic acid tert-butyl ester (350 mg, 0.0007 mol) and NH4Cl (310 mg, 0.006 mol) in water and THF (10 mL). The resulting mixture was stirred at room temperature for 40 minutes. The reaction was monitored by TLC (100% ethylacetate). The reaction mixture was concentrated and partitioned between ethylacetate and water. The organic layer was washed with saturated NaHCO3 solution and concentrated to afford 150 mg of the crude product which was used in the next step without further purification.

1. concentrationThe reaction mixture was concentrated
2. custompartitioned between ethylacetate and water
3. washThe organic layer was washed with saturated NaHCO3 solution
4. concentrationconcentrated