反应详情

Using the same reaction conditions, procedure and work up as described for the preparation of Intermediate I-25c (below), potassium 3-(1,3-bis(benzyloxy)propan-2-yl)cyclobutane-1-sulfonate (0.5 g, 1.168 mmol) was reacted with POCl3 (0.22 mL, 2.336 mmol), diisopropyl ethyl amine (0.4 mL, 2.336 mmol) and DCM (20 mL) to afford the crude product. Purification by column chromatography on silica gel (8% ethyl acetate in hexane) afforded 0.32 g of the product (68% yield).

1. customthe same reaction conditions, procedure
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (8% ethyl acetate in hexane)