反应详情

2-bromo-5-[N-(tert-butoxycarbonyl)-4-cyanophenylamino]benzyl acetate (3.02 g, 6.78 mmol) was treated with 4 mol/L hydrogen chloride in dioxane (20 mL) at room temperature for two hours. This was neutralized with 1 mol/L sodium hydroxide to PH=6 to 7 in ice-water bath and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 2-bromo-5-(4-cyanophenylamino)benzyl acetate, which was used for the next step without purification.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. customThe solvent was removed under reduced pressure