反应详情

0.26 g of acetic acid 3-{(S)-3-[4-(4-isopropyl-benzenesulfonylamino)-phenyl]-pyrrolidin-1-yl}-propyl ester (0.58 mmol) were dissolved in 4 ml of tetrahydrofuran. 0.021 g lithium hydroxide (0.88 mmol) dissolved in 4 ml water were added and the reaction mixture stirred for 15 h at room temperature. An additional equivalent of lithium hydroxide was added and stirring continued for 24 h before the reaction mixture was diluted with water and extracted three times with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered, and evaporated to dryness under reduced pressure to yield 0.157 g of the product.

1. additionwere added
2. stirringstirring
3. waitcontinued for 24 h before the reaction mixture
4. extractionextracted three times with ethyl acetate
5. dry with materialThe combined organic phases were dried over magnesium sulfate
6. filtrationfiltered
7. customevaporated to dryness under reduced pressure