Pyridine, 2-(4-nitro-1H-imidazol-1-yl)- → HCID 66520792, compound

HRID 1260320Notes

Reaction equation

HRID 1260320 reaction equation
[N+:1]([C:4]1[N:5]=[CH:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:8]=1)([O-])=O.[H][H]>C1COCC1.[Pd]>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[N:7]1[CH:8]=[C:4]([NH2:1])[N:5]=[CH:6]1

Participants

5

Reactant 2

HCID 10856269Pyridine, 2-(4-nitro-1H-imidazol-1-yl)-HCID 178418361HCID 178418361, compound

Product 1

HCID 66520792HCID 66520792, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(4-nitro-imidazol-1-yl)-pyridine (150 mg, 0.79 mmol) in THF (12 ml) was added under inert gas atmosphere 10% Pd/C (28 mg, 0.026 mmol). Upon evacuation, the reaction vessel was charged with hydrogen and the reaction mixture was stirred at ambient temperature overnight. The catalyst was filtered off, the solvent volume was reduced and the amine was used without any further purification as ˜0.2 M THF solution for the next step.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe amine was used without any further purification as ˜0.2 M THF solution for the next step

Sources & evidence

ORD record
ord-60abcf0546174b9baf8540bb806bc249
Source dataset
uspto-grants-2013_06
Patent number
US08470820B2

Reaction notes

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