Trifluoroacetic acid → HCID 67071818, compound

HRID 1260528Notes

Reaction equation

HRID 1260528 reaction equation
[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][C:12]2[CH:29]=[CH:28][C:15]([O:16][CH2:17][CH:18]([NH:20]C(=O)OC(C)(C)C)[CH3:19])=[CH:14][CH:13]=2)=[N:9][CH:10]=1)([CH3:3])[CH3:2].[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][C:12]2[CH:29]=[CH:28][C:15]([O:16][CH2:17][CH:18]([NH2:20])[CH3:19])=[CH:14][CH:13]=2)=[N:9][CH:10]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86761883HCID 86761883, compound

Product 1

HCID 67071818HCID 67071818, compound

Procedure

tert-Butyl {2-[4-(5-isopropoxypyridin-2-yloxy)phenoxy]-1-methylethyl}carbamate (414 mg, 1.03 mmol) was treated with 90% strength trifluoroacetic acid for 4 h. The trifluoroacetic acid was distilled off and the aqueous phase was freeze dried. The crude product contains excess trifluoroacetic acid and was further reacted without purification.

Workup

  1. distillationThe trifluoroacetic acid was distilled off
  2. customdried
  3. customwas further reacted without purification

Sources & evidence

ORD record
ord-9297748bf7c24bbd8325d591c5ac0c1c
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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