N-[3-(4-Hydroxyphenyl)-1-methylpropyl]acetamide → HCID 49858095, compound

HRID 1260559Notes

Reaction equation

HRID 1260559 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]([NH:12][C:13](=[O:15])[CH3:14])[CH3:11])=[CH:4][CH:3]=1.[H][H]>C(O)C.[Rh]>[OH:1][CH:2]1[CH2:3][CH2:4][CH:5]([CH2:8][CH2:9][CH:10]([NH:12][C:13](=[O:15])[CH3:14])[CH3:11])[CH2:6][CH2:7]1

Participants

5

Reactant 2

HCID 59956161N-[3-(4-Hydroxyphenyl)-1-methylpropyl]acetamideHCID 178418361HCID 178418361, compound

Product 1

HCID 49858095HCID 49858095, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 702EthanolSolvent

Procedure

N-[3-(4-Hydroxyphenyl)-1-methylpropyl]acetamide (1.0 g, 4.82 mmol) were dissolved in 100 ml of ethanol and hydrogenated in the presence of 5% rhodium on carbon (695 mg) at 100° C. and 100 bar hydrogen pressure for 18 h. The catalyst was filtered off and the filtrate was concentrated. Yield: 1.06 g of crude product, M+H+: 214.2.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-b016762b2f3047b5a1ce06c92fc13e19
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

Loading…