反应详情

Trans-{4-[2-(4-thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester (605 mg, 1.36 mmol) was dissolved in a mixture of EtOAc (10 ml) and MeOH (1 ml) and treated with 2 N HCl in Et2O (10 ml, 20 mmol). The resulting mixture was stirred 5 h at room temperature. A white precipitate was formed that was collected by filtration and washed with EtOAc. The solid was dried over night under high vacuum to yield trans-4-[2-(4-thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride as a white solid (365 mg, 59%), MS (ISP) m/z=345.2 [(M+H)+].

1. customA white precipitate was formed
2. filtrationthat was collected by filtration
3. washwashed with EtOAc
4. customThe solid was dried over night under high vacuum