Methyl 3,3-dimethoxypropionate → HCID 178495584, compound

HRID 1260762Notes

Reaction equation

HRID 1260762 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[CH3:28][O:29][CH:30]([O:36][CH3:37])[CH2:31][C:32](OC)=[O:33]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:32](=[O:33])[CH2:31][CH:30]([O:36][CH3:37])[O:29][CH3:28])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 81924Methyl 3,3-dimethoxypropionateHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178495584HCID 178495584, compound

Procedure

The title compound, white solid (103 mg, 92%), MS (ISP) m/z=447.4 [(M+H)+], mp 218° C., was prepared in accordance with the general method of example 5 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and methyl 3,3-dimethoxy-propanoate.

Sources & evidence

ORD record
ord-0410882c2ebf41179d51d7a41302d3eb
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

Loading…