Dimethylcarbamoyl Chloride → HCID 178484726, compound

HRID 1260792Notes

Reaction equation

Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[CH3:28][N:29]([CH3:33])[C:30](Cl)=[O:31]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:30](=[O:31])[N:29]([CH3:33])[CH3:28])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

Reactant 2

HCID 6598Dimethylcarbamoyl Chloride

HCID 178478590HCID 178478590, compound2×

Product 1

HCID 178484726HCID 178484726, compound

Procedure

The title compound, white solid (81 mg, 81%), MS (ISP) m/z=402.5 [(M+H)+], mp 217.5° C., was prepared in accordance with the general method of example 26 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and dimethylcarbamic acid chloride.

Sources & evidence

ORD record: ord-7b958a13e9a64fac9427f7cd608cc4ee
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470828B2

Reaction notes

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