反应详情

温度

100 °C

(Step 3) To a solution of 2-amino-5-chloronicotinamide (0.15 g) in N,N-dimethylformamide (3 ml) was added 3-(bromomethyl)-5-chlorobenzamide (0.26 g) obtained in Step 2, and the mixture was stirred at 100° C. for 3 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (110 mg).

1. filtrationThe precipitate was collected by filtration
2. washwashed with ethyl acetate
3. customThe obtained precipitate was recrystallized from methanol-ethyl acetate