Sodium ion → (1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

HRID 126109Notes

Reaction equation

HRID 126109 reaction equation
[Al+3:32].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[Cl:1][c:2]1[cH:3][c:4]([F:30])[c:5]([CH2:6][n:7]2[cH:8][cH:9][c:10]3[c:11]2[n:12][c:13]([CH3:27])[c:14]([C:23](=[O:24])[O:25][CH3:26])[c:15]3-[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[cH:28][cH:29]1.[H-:31].[H-:34].[H-:35].[H-:36].[Li+:33].[Na+:39].[OH-:38].[OH2:37]>>[Cl:1][c:2]1[cH:3][c:4]([F:30])[c:5]([CH2:6][n:7]2[cH:8][cH:9][c:10]3[c:11]2[n:12][c:13]([CH3:27])[c:14]([CH2:23][OH:24])[c:15]3-[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[cH:28][cH:29]1

Participants

9

Reactant 8

HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 71209420methyl 1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Product 1

HCID 71209184(1-(4-chloro-2-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

Sources & evidence

ORD record
ord-89cd164ef9ac468a92534c83b15bb4bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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