反应详情

温度

110 °C

To a solution of methyl (3S)-3-[(tert-butoxycarbonyl)amino]-1-(1-hydroxy-1-methylethyl)cyclopentanecarboxylate (1.0 g, 3.3 mmol) in a mixture of tetrahydrofuran (30 mL), methanol (30 mL) and water (6 mL) was added Lithium hydroxide monohydrate (0.22 g, 5.3 mmol) and the mixture refluxed overnight (110° C.). The organic solvents were evaporated and the aqueous layer was washed with ether one time. The aqueous layer was then acidified with 6 N HCl to about pH 4 and extracted with methylene chloride three times. The combined extracts were dried, filtered, and concentrated to provide the desired product (0.47 g, 49%).

1. customThe organic solvents were evaporated
2. washthe aqueous layer was washed with ether one time
3. extractionextracted with methylene chloride three times
4. customThe combined extracts were dried
5. filtrationfiltered
6. concentrationconcentrated