Benzyl isocyanate → HCID 66778751, compound

HRID 1261733Notes

Reaction equation

HRID 1261733 reaction equation
[CH2:1]([N:8]=[C:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[N:12]1[C:21]2[CH2:20][CH2:19][NH:18][CH2:17][C:16]=2[CH:15]=[CH:14][C:13]=1[C:22]([O:24][CH3:25])=[O:23].CCN(C(C)C)C(C)C>CN(C=O)C>[CH2:1]([NH:8][C:9]([N:18]1[CH2:19][CH2:20][C:21]2[N:12]=[C:13]([C:22]([O:24][CH3:25])=[O:23])[CH:14]=[CH:15][C:16]=2[CH2:17]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 76639Benzyl isocyanateHCID 81531DiisopropylethylamineHCID 56847101HCID 56847101, compound

Product 1

HCID 66778751HCID 66778751, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a vial containing benzyl isocyanate (0.0166 g, 0.125 mmol), was added methyl 5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylate hydrochloride (0.0220 g, 0.0962 mmol), DIPEA (0.0586 mL, 0.337 mmol) and DMF (2 mL). The resulting solution was then shaken at rt for 13 h and then concentrated to give methyl 6-(benzylcarbamoyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylate.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-d0a5568eed054569a6e8c29184110dbd
Source dataset
uspto-grants-2013_06
Patent number
US08471026B2

Reaction notes

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