1-Butanesulfonyl chloride → HCID 66778571, compound

HRID 1261735Notes

Reaction equation

HRID 1261735 reaction equation
[CH2:1]([S:5](Cl)(=[O:7])=[O:6])[CH2:2][CH2:3][CH3:4].Cl.[N:10]1[C:19]2[CH2:18][CH2:17][NH:16][CH2:15][C:14]=2[CH:13]=[CH:12][C:11]=1[C:20]([O:22][CH3:23])=[O:21]>CN(C1C=CN=CC=1)C.CN(C=O)C>[CH2:1]([S:5]([N:16]1[CH2:17][CH2:18][C:19]2[N:10]=[C:11]([C:20]([O:22][CH3:23])=[O:21])[CH:12]=[CH:13][C:14]=2[CH2:15]1)(=[O:7])=[O:6])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 754301-Butanesulfonyl chlorideHCID 56847101HCID 56847101, compound

Product 1

HCID 66778571HCID 66778571, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6228DimethylformamideSolvent

Procedure

To a microwave vial containing n-butanesulfonyl chloride (0.0352 g, 0.225 mmol), was added methyl 5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylate hydrochloride (0.0288 g, 0.15 mmol), TEA (0.167 mL, 1.2 mmol), DMAP (1.83 mg, 0.015 mmol), and DMF (2 mL). The mixture was shaken at rt for 13 h. The solvent was then completely evaporated to yield a solid. LC-MS: (FA) ES+ 313.

Workup

  1. customThe solvent was then completely evaporated
  2. customto yield a solid

Sources & evidence

ORD record
ord-b84f8a2d58cc40b6a5f66f22c4e9925d
Source dataset
uspto-grants-2013_06
Patent number
US08471026B2

Reaction notes

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