Dimethylformamide → HCID 57913436, compound

HRID 1261744Notes

Reaction equation

HRID 1261744 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH:8]=[O:9])[C:5](Cl)=[CH:4][C:3]=1[CH:11]=[O:12].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C.[C:24]1([SH:30])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O>[C:24]1([S:30][C:2]2[CH:7]=[C:6]([CH:8]=[O:9])[C:5]([S:30][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:4][C:3]=2[CH:11]=[O:12])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 7969ThiophenolHCID 11430Potassium CarbonateHCID 6085402,5-Dichloroterephthalaldehyde

Product 1

HCID 57913436HCID 57913436, compoundYield 69.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A 500 ml Schlenk flask is charged under an inert atmosphere with 2,5-Dichloro-benzene-1,4-dicarbaldehyde (30.45 g, 0.15 mol), potassium carbonate (62.1 g, 0.45 mol) and dry DMF (200 ml). The flask is immersed in an oil bath of 80° C., and then without delay thiophenol (33.0 g, 0.3 mol) is added via a dropping funnel within 15 minutes. To the formed brown suspension is added water (ca. 100 ml) and the mixture is stirred for another 5 minutes. Then the contents of the flask are poured as a thin stream into a beaker which containd 2 L of vigorously stirred water. A yellow solid precipitates, and the mixture is stirred for another hour. The solid is then filtered off, washed with water (twice 250 ml), and recrystallised without further drying from THF (ca. 200 ml). The crystals of the product are filtered off, washed with little iso-propanol (ca. 50 ml) and dried to give the product (36.75 g). From the mother liquors most of the THF is removed on the rotavapor which leads to the crystallisation of another crop. This material is also filtered off and washed with little iso-propanol to give another 4.72 g of product. Bright yellow crystals, mp. 163° C. 1H-NMR (CDCl3, 300 MHz) δ 7.39 (phenyl para H); 7.40 (phenyl ortho H)); 7.41 (phenyl meta H); 7.58 (s, aryl CH); 10.27 (s, 1H, CHO). 13C-NMR (CDCl3, 75 MHz) δ 129.18 (phenyl para CH); 130.19 (phenyl ortho CH); 132.47 (phenyl ipso C); 133.20 (phenyl meta CH); 133.75 (aryl CH); 136.79 (CCHO); 139.54 (CS); 190.45 (CHO).

Workup

  1. customThe flask is immersed in an oil bath of 80° C.
  2. additionThen the contents of the flask are poured as a thin stream into a beaker which
  3. customA yellow solid precipitates
  4. stirringthe mixture is stirred for another hour
  5. filtrationThe solid is then filtered off
  6. washwashed with water (twice 250 ml)
  7. customrecrystallised
  8. dry with materialwithout further drying from THF (ca. 200 ml)
  9. filtrationThe crystals of the product are filtered off
  10. washwashed with little iso-propanol (ca. 50 ml)
  11. customdried

Sources & evidence

ORD record
ord-15ac090b784441a3af47bb9c8a367ed8
Source dataset
uspto-grants-2013_06
Patent number
US08471019B2

Reaction notes

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