Hydrochloric Acid → 3-(4-carboxy-2-oxo-2H-pyridin-1-ylmethyl)-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

HRID 1261784노트

반응식

HRID 1261784 반응식
[CH3:1][O:2][C:3]([C:5]1[N:6]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:7]2[C:12]([C:13](=[O:27])[C:14]=1[CH2:15][N:16]1[CH:21]=[CH:20][C:19]([C:22]([O:24]C)=[O:23])=[CH:18][C:17]1=[O:26])=[CH:11][CH:10]=[C:9]([Cl:28])[CH:8]=2)=[O:4].[OH-].[Na+].Cl>O1CCCC1>[CH3:1][O:2][C:3]([C:5]1[N:6]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:7]2[C:12]([C:13](=[O:27])[C:14]=1[CH2:15][N:16]1[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][C:17]1=[O:26])=[CH:11][CH:10]=[C:9]([Cl:28])[CH:8]=2)=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 708168387-chloro-3-(4-methoxycarbonyl-2-oxo-2H-pyridin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

생성물 1

HCID 708171503-(4-carboxy-2-oxo-2H-pyridin-1-ylmethyl)-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
25 °C

실험 절차

A solution of 7-chloro-3-(4-methoxycarbonyl-2-oxo-2H-pyridin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester (0.22 g, 459 μmol) in tetrahydrofuran (10 mL) at 25° C. was treated with a 1N aqueous sodium hydroxide solution (0.7 mL, 459 μmol). The reaction was stirred at 25° C. for 2 h. At this time, the reaction was acidified with a 1N aqueous hydrochloric acid solution and then concentrated in vacuo to afford 3-(4-carboxy-2-oxo-2H-pyridin-1-ylmethyl)-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester. The material was used without further purification.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-94c2035d25f14872ad6df4bbdd28150e
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08471027B2

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