反应详情

温度

25 °C

A solution of 7-chloro-3-(4-methoxycarbonyl-2-oxo-2H-pyridin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester (0.22 g, 459 μmol) in tetrahydrofuran (10 mL) at 25° C. was treated with a 1N aqueous sodium hydroxide solution (0.7 mL, 459 μmol). The reaction was stirred at 25° C. for 2 h. At this time, the reaction was acidified with a 1N aqueous hydrochloric acid solution and then concentrated in vacuo to afford 3-(4-carboxy-2-oxo-2H-pyridin-1-ylmethyl)-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester. The material was used without further purification.

1. concentrationconcentrated in vacuo