反应详情

The acridine prepared above and triethylamine (1.4 ml) are charged into a glass reaction vessel equipped with a stirrer and thermometer. To this is added a cooled solution (0° C.) of O-ethyl S-propyl phosphorochloridothioate (0.01 mole) in toluene (25 ml). The mixture is stirred with continued cooling for 1/2 hour and thereafter at room temperature overnight. After this time the reaction mixture is filtered to remove triethylamine hydrochloride and the filtrate is stripped of solvent in a rotary evaporator leaving a residue. This residue is subjected to flash chromatography using ethyl acetate as the eluant to yield the desired product.

1. additionare charged into a glass reaction vessel
2. customequipped with a stirrer
3. temperaturewith continued cooling for 1/2 hour
4. customat room temperature
5. customovernight
6. filtrationAfter this time the reaction mixture is filtered
7. customto remove triethylamine hydrochloride
8. customthe filtrate is stripped of solvent in a rotary evaporator
9. customleaving a residue