Hydrochloric Acid → HCID 20456493, compound

HRID 1263043Notes

Reaction equation

HRID 1263043 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([C:10]1[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:11]=1[C:12]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:13])=[O:9].[ClH:27]>C1COCC1>[ClH:27].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([C:10]1[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:11]=1[C:12]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:13])=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20456494HCID 20456494, compound

Product 1

HCID 20456493HCID 20456493, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-(2-Pyridylacetyl)-p-anisanilide (II) (25.0 g, 0.0722 mole) was dissolved with gentle warming in 500 ml THF. The bright yellow solution was chilled in an ice bath, and 6.5 ml (0.078 mole) 12 N HCl was added. The yellow color disappeared and a white precipitate formed immediately. The solid was collected on a filter; rinsed with THF and air-dried to give 27.4 g white solid (99.3%), m.p. 190.5°-191.5° (dec.).

Workup

  1. temperatureThe bright yellow solution was chilled in an ice bath
  2. customa white precipitate formed immediately
  3. customThe solid was collected on a filter
  4. washrinsed with THF
  5. customair-dried

Sources & evidence

ORD record
ord-5ac1fa96555e4d02be04d04be55eb74e
Source dataset
uspto-grants-1984_06
Patent number
US04454324

Reaction notes

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