Potassium Carbonate → HCID 20455678, compound

HRID 1263061Notes

Reaction equation

HRID 1263061 reaction equation
[NH2:1][C:2]1[N:11]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:21]([CH3:23])[CH3:22])[CH:8]=2)[N:3]=1.C(=O)([O-])[O-].[K+].[K+].I[CH2:31][C:32](OCC)=[O:33]>CN(C)C=O>[CH3:23][N:21]([CH3:22])[C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]1[CH2:31][C:32](=[O:33])[N:1]=[C:2]1[N:11]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)[CH2:10]2

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 12183Ethyl iodoacetateHCID 20455667HCID 20455667, compound

Product 1

HCID 20455678HCID 20455678, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 19.5 g of 2-amino-6-dimethylamino-3,4-dihydro-3-(p-methoxybenzyl)-quinazoline in 300 ml of dimethylformamide was treated with 90 g of potassium carbonate and 12.9 g of ethyl iodoacetate and the mixture was stirred at room temperature for 20 hours and then at 85° for 5 hours. The mixture was then cooled, poured into ice/water and the crude product was filtered. Pure 7-dimethylamino-4,5-dihydro-4-(p-methoxybenzyl)-imidazo[1,2-a]quinazolin-2(1H)-one of melting point 196°-200° was obtained by recrystallization from methanol.

Workup

  1. waitat 85° for 5 hours
  2. temperatureThe mixture was then cooled
  3. filtrationthe crude product was filtered

Sources & evidence

ORD record
ord-3a9fa302af564c9893b3921b95127f58
Source dataset
uspto-grants-1984_06
Patent number
US04455311

Reaction notes

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