反应详情

To ethyl glycinate hydrochloride (36.4 g) suspended in 500 ml methylene chloride were added magnesium sulfate (22 g) and triethylamine (72 ml, 52.4 g). Benzaldehyde (27.6 g) was added dropwise at 15°-20° C. with stirring. The mixture was stirred at room temperature for two hours, filtered and stripped. To the residue was added 300 ml diethylether and 150 ml brine. After separation the organic layer was collected, and the aqueous layer was extracted with 100 ml ether. The organic phases were combined, dried (MgSO4), filtered and stripped to yield the title product as a pale yellow oil.

1. stirringThe mixture was stirred at room temperature for two hours
2. filtrationfiltered
3. additionTo the residue was added 300 ml diethylether and 150 ml brine
4. customAfter separation the organic layer
5. customwas collected
6. extractionthe aqueous layer was extracted with 100 ml ether
7. dry with materialdried (MgSO4)
8. filtrationfiltered