Acetic Acid → HCID 178491996, compound

HRID 1263243Notes

Reaction equation

HRID 1263243 reaction equation
[CH3:1][O:2][CH:3]([O:23][CH3:24])[CH2:4][NH:5][C:6]([NH:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=[S:7].[I:25]C.[C:27](O)(=O)C.O(C(C)C)C(C)C>C(OCC)(=O)C>[IH:25].[CH3:24][O:23][CH:3]([O:2][CH3:1])[CH2:4][NH:5][C:6]([S:7][CH3:27])=[N:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 6328Methyl iodideHCID 7914Diisopropyl EtherHCID 12952717HCID 12952717, compound

Product 1

HCID 178491996HCID 178491996, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 5.3 parts of N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]thiourea, 6 parts of iodomethane, 5 parts of acetic acid and 90 parts of ethyl acetate is stirred for 2 days at room temperature. Upon the addition of 2,2'-oxybispropane, the product is crystallized. It is filtered off and dried, yielding 6 parts (80%) of methyl N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]carbamimidothioate monohydroiodide.

Workup

  1. customthe product is crystallized
  2. filtrationIt is filtered off
  3. customdried

Sources & evidence

ORD record
ord-7eb3dc22007d40cbbc11a04db17baf41
Source dataset
uspto-grants-1984_06
Patent number
US04456605

Reaction notes

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