Hydrochloric Acid → HCID 12952783, compound

HRID 1263247Notes

Reaction equation

HRID 1263247 reaction equation
[CH3:1][O:2][CH:3](OC)[CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[S:7].Cl.C(=O)([O-])O.[Na+]>>[CH3:1][O:2][CH:3]1[S:7][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[N:5][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 12952797HCID 12952797, compound

Product 1

HCID 12952783HCID 12952783, compoundYield 73%

Procedure

A mixture of 6 parts of N-(2,2-dimethoxyethyl)-4-(4-hydroxyphenyl)-1-piperazinecarbothioamide and 25 parts of a diluted hydrochloric acid solution is stirred overnight at room temperature. Upon the addition of sodium hydrogen carbonate, the product is allowed to crystallize. It is filtered off and recrystallized from ethanol, yielding 4.3 parts (73%) of 4-[4-(4,5-dihydro-5-methoxy-2-thiazolyl)-1-piperazinyl]phenol; mp. 165.6° C.

Workup

  1. customto crystallize
  2. filtrationIt is filtered off
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-2b635828b7b2460d9a5882c023b12102
Source dataset
uspto-grants-1984_06
Patent number
US04456605

Reaction notes

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