N-Phenylmaleimide → HCID 13547662, compound

HRID 1263305Notes

Reaction equation

HRID 1263305 reaction equation
[C:1]([C:5]1[CH:10]=[C:9]([SH:11])[CH:8]=[C:7]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[OH:16])([CH3:4])([CH3:3])[CH3:2].[C:17]1([N:23]2[C:27](=[O:28])[CH:26]=[CH:25][C:24]2=[O:29])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(N(CC)CC)C>[C:17]1([N:23]2[C:27](=[O:28])[CH2:26][CH:25]([S:11][C:9]3[CH:8]=[C:7]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]([OH:16])=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:10]=3)[C:24]2=[O:29])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 13662N-PhenylmaleimideHCID 703702,6-Di-tert-butyl-4-mercaptophenol

Product 1

HCID 13547662HCID 13547662, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure of Example 1 is repeated using 10 grams of 2,6-di-tert-butyl-4-mercaptophenol, 7.26 grams of N-phenyl maleimide, and 0.73 grams of triethylamine. The residue is recrystallized from isopropanol to give 2.3 grams (48% yield) of white solid, m.p. 134°-137° C.

Workup

  1. customThe residue is recrystallized from isopropanol

Sources & evidence

ORD record
ord-afb00246594b4b449bc2077028d30695
Source dataset
uspto-grants-1984_06
Patent number
US04456716

Reaction notes

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